3/17/2026
IgPose: A Generative Data-Augmented Pipeline for Robust Immunoglobulin-Antigen Binding Prediction
Generative data augmentation pipeline for immunoglobulin-antigen binding prediction using synthetic data to address data scarcity.
3/17/2026
Seismic full-waveform inversion based on a physics-driven generative adversarial network
Physics-driven generative adversarial network for seismic full-waveform inversion to reconstruct subsurface velocity models.
3/17/2026
Informative Perturbation Selection for Uncertainty-Aware Post-hoc Explanations
Post-hoc explanation method using informative perturbation selection for model-agnostic ML explanations with uncertainty quantification.
3/17/2026
BiTro: Bidirectional Transfer Learning Enhances Bulk and Spatial Transcriptomics Prediction in Cancer Pathological Images
Bidirectional transfer learning framework for predicting transcriptomics from cancer pathological images and spatial transcriptomics data.
3/17/2026
Directional Routing in Transformers
Introduces directional routing mechanism for transformer attention heads with learned suppression directions, analyzed via mechanistic interpretability.
3/17/2026
LLM as Graph Kernel: Rethinking Message Passing on Text-Rich Graphs
Proposes using LLMs as graph kernels for learning on text-rich graphs, treating text dynamically in message passing instead of static embeddings.
3/17/2026
Ultra-Early Prediction of Tipping Points: Integrating Dynamical Measures with Reservoir Computing
Framework using reservoir computing to predict tipping points in complex dynamical systems like climate and ecosystems.
3/17/2026
Spiking Layer-Adaptive Magnitude-based Pruning
Proposes magnitude-based pruning strategy for spiking neural networks to reduce connectivity and computation costs while maintaining performance.
3/17/2026
FairMed-XGB: A Bayesian-Optimised Multi-Metric Framework with Explainability for Demographic Equity in Critical Healthcare Data
Fairness-aware XGBoost framework detects and mitigates gender bias in critical care predictions while maintaining explainability.
3/17/2026
SFedHIFI: Fire Rate-Based Heterogeneous Information Fusion for Spiking Federated Learning
Heterogeneous spiking federated learning framework using fire-rate fusion for resource-constrained clients with SNNs.
3/17/2026
Lightweight User-Personalization Method for Closed Split Computing
Lightweight personalization method for split computing inference on edge devices handling distribution shifts and communication unreliability.
3/17/2026
How Log-Barrier Helps Exploration in Policy Optimization
Log-barrier regularization improves exploration in Stochastic Gradient Bandit algorithm for policy optimization with global convergence guarantees.
3/17/2026
MONET: Modeling and Optimization of neural NEtwork Training from Edge to Data Centers
MONET framework models neural network training efficiency from edge to data centers, capturing memory and backpropagation constraints.
3/17/2026
TrajFlow: Nation-wide Pseudo GPS Trajectory Generation with Flow Matching Models
Flow matching generates pseudo GPS trajectory data at nation-wide scale for privacy-preserving mobile data applications.
3/17/2026
Rethinking Machine Unlearning: Models Designed to Forget via Key Deletion
Machine unlearning approach designs models with key deletion mechanism to erase training sample influence without full training data access.
3/17/2026
CrossADR: enhancing adverse drug reactions prediction for combination pharmacotherapy with cross-layer feature integration and cross-level associative learning
Graph-based method predicts adverse drug reactions for combination pharmacotherapy using cross-layer feature integration and associative learning.
3/17/2026
Muon Converges under Heavy-Tailed Noise: Nonconvex H\"{o}lder-Smooth Empirical Risk Minimization
Muon optimizer enforces orthogonality via Stiefel manifold projection for stable neural network training under heavy-tailed noise conditions.
3/17/2026
Show HN: Skill-Crypt – encrypted skill sharing between AI agents over XMTP
System for encrypted skill sharing between AI agents using AES-256-GCM encryption over XMTP protocol.
3/17/2026
More transparency and control over Gemini API costs
Google AI Studio adds Project Spend Caps and revised Usage Tiers for controlling Gemini API monthly costs.
3/17/2026
Show HN: TLA PreCheck – TS DSL that proves state machines via TLA+
TypeScript DSL using TLA+ model checking to prove state machine correctness and generate runtime code.
3/17/2026
Libgoc: A Go-style CSP concurrency runtime for C
Go-style CSP concurrency runtime library for C with coroutines, channels, and garbage collection.
3/17/2026
AI still doesn't work well, businesses are faking it, and a reckoning is coming
Interview discussing enterprises struggling to implement AI with authentic use cases and faking adoption.
3/17/2026
Show HN: Self-orchestrating engineering team for Claude Code
Six AI agents for Claude Code that run locally in markdown files with no external dependencies, platform, or data collection.
3/17/2026
Show HN: I turned my Claude Max subscription into a 24/7 AI company
Project using Claude API subscription for autonomous task automation. Minimal technical details.
3/16/2026
Elon Musk's xAI sued for turning three girls' real photos into AI CSAM
Legal case against xAI alleging Grok generated CSAM from real photos. News coverage.
3/16/2026
Context Hub gives agents curated, versioned docs
Context Hub provides versioned, curated API documentation for coding agents to reduce hallucination and improve learning across sessions.
3/16/2026
Show HN: ssh.bot – Controlled SSH Access for AI Agents
ssh.bot provides controlled SSH access for AI agents with granular permissions, audit trails, and kill-switch controls.
3/16/2026
Stream0, the messaging layer for AI agents. HTTP-native, event-driven
Stream0 messaging infrastructure for multi-agent communication with persistent inboxes and mid-task conversations.
3/16/2026
Show HN: Browse-your-way – use LLMs to browse a customizable web
LLM-powered web browsing tool with customizable interface. Limited details provided.
3/16/2026
Show HN: AI Products Quality Monitoring
Monitoring platform tracking AI product quality across models and endpoints with real-time user experience metrics.
3/16/2026
Show HN: pg_typescript, a Postgres extension for writing functions in TypeScript
PostgreSQL extension enabling TypeScript function writing via Deno runtime with Node.js API support. Alpha quality.
3/16/2026
Show HN: BonzAI – 1-click local AI inference and yield-bearing AI artifacts
Local AI inference platform replacing online stack with open-weight models, FLUX, and alternative LLM services.
3/16/2026
Cnsplots: A Python library for Cell, Nature, and Science quality plots
Python visualization library for creating publication-ready scientific figures optimized for Cell, Nature, Science journals.
3/16/2026
MIDI 2.0 (and enhanced MIDI 1.0) comes to Windows 11
MIDI 2.0 and enhanced MIDI 1.0 support now available on Windows 11 for music production and hardware control.
3/16/2026
API tests as files instead of Postman collections (Skivvy)
CLI tool for declarative HTTP API testing via JSON files supporting REST, GraphQL, and CI/CD integration.
3/16/2026
How do you turn readers into participants in a new AI community?
Sponsorship/ad placement content with no technical substance.
3/16/2026
The four levels of AI-driven engineering
Framework describing four levels of AI-driven engineering adoption, from code assistance to autonomous multi-step agent systems.
3/16/2026
An AI agent improved OWASP CRS detection by 80% in 20 autonomous experiments
AI agent autonomously improved OWASP CRS regex detection rules: TPR 55.8%→100%, FPR 29.7%→4.8% across 20 experiments with 0 rejections.
3/16/2026
Show HN: GitHub Copilot Now Supports MCP
GitHub Copilot adds Model Context Protocol support enabling persistent memory and external tool integration in Agent Mode.
3/16/2026
Show HN: Created a tool that prevents accidental pasting of PII in AI prompts
Shhh: tool masking PII in AI prompts by replacing secrets with realistic fakes while preserving data structure for model reasoning.
3/16/2026
Show HN: Lens – Open-weight AI model to identify fonts from images
Open-weight font recognition model identifying fonts from images with full inference stack and weights released.
3/16/2026
The flip side of AI ingenuity (DeepMind, 2020)
DeepMind research on specification gaming: when AI systems satisfy literal objectives without achieving intended outcomes, with examples and implications.
3/16/2026
Show HN: AllMy Ledger – Desktop accounting software, one-time purchase, no cloud
Desktop accounting software for freelancers with local data ownership and no subscription model.
3/16/2026
The day Point Loma launched a ship made of concrete
Historical account of US concrete shipbuilding efforts post-World War I to address steel scarcity.
3/16/2026
AI agents framework for TypeScript and Deno
Vibes: TypeScript/Deno AI agent framework for type-safe production applications supporting 50+ LLM providers via Vercel AI SDK.
3/16/2026
AI as Economic Warfare
Opinion piece comparing open-source AI models to historical Linux vs Windows competition and economic implications.
3/16/2026
Show HN: LynString – Translate Android Strings.xml with AI
LynString: AI tool for translating missing strings in Android projects with one-click localization for multiple locales.
3/16/2026
AI is helping choose targets in Iran war – now it's a target too
News story about Amazon data centers in UAE being struck by Iranian drones, discussing AI's role in military targeting.
3/16/2026
Show HN: YouTube video discovery engine for language learning
YouTube video discovery system for language learning using content matching and proficiency-level filtering.
3/16/2026
Show HN: Cozystack v1.0 – an open-source cloud platform for bare metal
Open-source cloud platform turning bare metal into managed infrastructure with VMs, Kubernetes, databases, and GPU services.